For example, weight training is also a kind of stress. Specialists will confirm that they cause micro-ruptures in the muscle fibers ... and the healing of these lesions becomes a stimulus to the growth and development of muscles. The first confirmation that stress in small doses can have beneficial effects on living organisms was obtained by the German pharmacist Hugo Schulz at the end of the 19th century. He found that the yeast developed more intensively if they added microdoses of toxic substances. This phenomenon was later called "hormesis", from the ancient Greek "excitement, stimulus". It manifests itself when living organisms face small doses of radiation, poisons, high temperatures and other harmful effects. When these doses are small enough that they can not cause serious damage, we see the opposite picture: to correct minor damage, the body activates internal resources and not only restores the damage, but improves the condition of the tissues compared to the original one. For details, see the article "The effect of sleep and stress on skin health".
Microdose effect
A world-famous biogerontologist Suresh Rattan from the University of Aarhus (Denmark) proposed the use of a hormesis mechanism to combat age-related changes. He proved that regular exposure to micro-doses of stress stimulates the protective response of cells and slows down the aging process. Such beneficial stress can create physical effects (high temperature, UV radiation, sports loads), eating habits (low calorie diet, some products - turmeric, ginger and others), psychological conditions (for example, excitement before performing in public). In 2002, Rattan and his colleagues studied the effect of small doses of stress on the synthesis of proteins in aging fibroblasts (cells responsible for the production of collagen and elastin). Scientists were interested in one of the so-called heat shock proteins (HSP70), which is involved in the body's response to stress. After a moderate heat shock, the level of this protein in the cells increased, and with it - resistance to ultraviolet and some toxic substances. Aging cells became significantly more active and resilient.
The vaccine against aging
Inspired by the discovery, the scientists of the laboratories teamed up with a group of scientists led by Rattan and created an anti-aging serum with a complex of active ingredients, which provoke hormesis, hormometins. In this case, they contribute to the production of this protein and thus inhibit the aging process. The complex includes extract of ginseng Sanchi and gipotaurin, which is obtained from taurine - one of the amino acids present in the human body.
Effect
In the course of the studies, it was found that, six hours after the application of serum, the production of HSP70 protein in cells increased by 24%. The clinical test showed that the skin's resistance to external influences after a month of using the serum increases by 3%. Indeed, microstresses trigger a complex chain of 3 response biochemical reactions in the body and activate including heat shock proteins. The hormetins not only help cells resist aging, but also increase the duration of the active life of the cell. Most leading European dermatologists and cosmetologists agree that the use of skin care products based on a deep understanding of human physiology and biochemistry on understanding the restorative properties of biological tissues can bring great success. The main thing is to ensure their correct use. Now we know what impact of sleep and stress on the health of the skin.